Anti-JUP Antibody(Monoclonal, 15F11)

货号:BM1576
应用:WB, IHC-F, ICC
反应性:Human,Bovine
克隆性:单克隆抗体
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产品概况

货号BM1576
产品名称Anti-JUP Antibody(Monoclonal, 15F11)
基因名JUP
抗体来源Mouse
克隆Monoclonal (Clone: 15F11)
抗体亚型Mouse IgG1
分子量82KD
免疫原Recombinant Chicken plakoglobin.
内容200ug/ml antibody with PBS ,0.02% NaN3 , 1mg BSA and 50% glycerol.
纯化方式Ascites
浓度200ug/ml
产品形态Liquid
保存条件12 months from date of receipt,-20℃ as supplied. 6 months 2 to 8℃ after reconstitution. Avoid repeated freezing and thawing.
背景资料Junction Plakoglobin(JUP) ,also knows as catenin gamma, is a major cytoplasmic protein that occurs in a soluble and a membrane-associated form and is the only known constituent common to the submembranous plaques of both kinds of adhering junctions, the desmosomes and the intermediate junctions. It is a component of the cadherin-catenin complex, which is predominantly localized where actin filaments anchor in adherens junctions of epithelial cells. The human plakoglobin gene localizes on chromosome 17q21. Gamma-catenin is regulated by the APC tumor suppressor and its oncogenic activity is distinct from that of beta-catenin.
研究类别1. Aberle, H.; Bierkamp, C.; Torchard, D.; Serova, O.; Wagner, T.; Natt, E.; Wirsching, J.; Heidkamper, C.; Montagna, M.; Lynch, H. T.; Lenoir, G. M.; Scherer, G.; Feunteun, J.; Kemler, R. : The human plakoglobin gene localizes on chromosome 17q21 and is subjected to loss of heterozygosity in breast and ovarian cancers. Proc. Nat. Acad. Sci. 92: 6384-6388, 1995. 2. Kolligs, F. T.; Kolligs, B.; Hajra, K. M.; Hu, G.; Tani, M.; Cho, K. R.; Fearon, E. R. : Gamma-catenin is regulated by the APC tumor suppressor and its oncogenic activity is distinct from that of beta-catenin. Genes Dev. 14: 1319-1331, 2000.
Uniprot IDJUP: P14923
推荐配套的二抗和检测试剂Boster recommends Enhanced Chemiluminescent Kit with anti-Mouse IgG (EK1001) for Western blot, and HRP Conjugated anti-Mouse IgG Super Vision Assay Kit (SV0001-1) for IHC(P) and ICC.

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